Compound or its pharmaceutically acceptable salt, pharmaceutical composition, and processes for treating or preventing diseases related to progesterone, breast cancer, ovarian cancer, hysteromyoma, endometriosis, meningioma, myeloma, osteoporosis, or climatic disorders, to cause an abortion, or to prevent orally conceiving

摘要

"COMPOUND OR ITS PHARMACEUTICALLY ACCEPTABLE SALT PHARMACEUTICAL COMPOSITION, AND, PROCESSES TO TREAT OR PREVENT PROGESTERONE-RELATED DISEASES, BREAST CANCER, OVARY CANCER, HISTEROMIOMA, CLOUDYMOROMYROMOMYROMINOMYTOMOROMYOMYROMATOMY, OR TO PREVENTLY PREVENT THE CONCEPTION ". Representative compounds are described by the formula (I) below or their pharmaceutically acceptable salts and a process for producing them. The compounds exhibit progesterone receptor binding inhibitory activity and therefore can be used as therapeutic and prophylactic agents for progesterone-related diseases. Specifically, they are useful as carcinostatic agents for breast cancer and ovarian cancer, as therapeutic agents for hysteromyoma, endometriosis, meningioma, and myeloma, abortion, oral contraceptive pills, and as therapeutic and prophylactic agents for osteoporosis and climacteric disturbances in which R ^ 1 ^ represents alkyl or aralkyl; R ^ 2 ^ represents a hydrogen atom, alkylcarbonyl, cycloalkylcarbonyl, aromatic acyl, heteroaromatic acyl, saturated heterocyclic acyl, alkyl, alkenyl, aralkyl, carbamoyl, alkylcarbamoyl, carbamoyl aromatic, aralkylcarbamoyl, alkylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonylcarbonate. saturated heterocyclic thiocarbonyl, or alkylthiocarbamoyl: and R3 represents a hydrogen atom, a hydroxyl, alkyloxy, alkylcarbonyloxy, alkylthio, or arylthio group.