Compounds, pharmaceutical compositions, and processes for preparing compounds and compositions and for treating central nervous system disorders.

摘要

"COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND PROCESSES TO PREPARE COMPOUNDS AND COMPOSITIONS AND TO TREAT DISORDERS OF THE CENTRAL NERVOUS SYSTEM". The invention relates to a group of new compounds of piperazine and piperidine, having interesting pharmacological properties. It has been found that the compounds of formula (a) in which - A represents a heterocyclic group of 5-7 atoms in the ring, where 1-3 heteroatoms of the group O, N and S are present, - R1 is hydrogen or fluoro, - R2 is C1-4 alkyl, C1-4 alkoxy or an oxo group and p is 0, 1 or - Z represents carbon or nitrogen and the dotted line is a single bond when Z is nitrogen and a single or double bond when Z is carbon, - R3 and R ~ 4 ~ are, independently, hydrogen or C1-4 alkyl. - n has a value of 1 or 2, - R ^ 5 ^ is 2-pyridyl, 3-pyridyl or 4-pyridyl substituted in the target position with respect to the methylene bridge with a group Y and, optionally, substituted with (R ~ 6 ~) ~ q ~, - Y is phenyl, furanyl or thienyl, groups which can be substituted by 1-3 substituents of the hydroxy, halogen, CF ~ 3 ~, C1-4 alkoxy, C1-4 alkyl group. cyano, aminocarbonyl, mono- or di-C1-4-alkylaminocarbonyl, - R6 is halogen, hydroxy, C1-4 alkoxy or C1-4 alkyl and q is 0, 1, 2 or 3 and their salts.