DERIVATIVES OF BENZOYLECGONINE, ECGONINE AND ECGONIDINE AS MEDICINES

摘要

A compound of formula (I), formula (II) or formula (III), wherein R1 isselected from the group consisting of H; branched or unbranched alkyl, alkenyland alkynyl, said alkyl, alkenyl and alkynyl being optionally substituted withOH, SH, NH2 or halogen; COCH3; COPh; and COBn; R2 is selected from thegroup consisting of branched or unbranched alkyl, alkeayl and alkynyl, saidalkyl,alkenyl and alkynyl being optionally substituted with OH, SH, NH2 or halogen;aryl; Het; and benzyl; R3 is selected from the group consisting of branchedor unbranched alkyl, alkenyl and alkynyl, said alkyl, alkenyl and alkynylbeingoptionally substituted with OH, SH, NH2 or halogen; R4 is selected from thegroupconsisting of H; and branched or unbranched alkyl, alkenyl and alkynyl, saidalkyl,alkenyl and alkynyl being optionally substituted with OH, SH, NH2 or halogen;andX is selected from the group consisting of OH; SH; NH2; and halogen: which areuseful for alleviating the symptoms of immunoregulatory disorders,neuromusculardisorders, joint disorders, connective tissue disorders, circulatory disordersand pain.