Prokinetic agents for treating gastric hypomotility and related disorders

摘要

The invention describes the use of PDE-4 (phosphodiesterase-4) inhibitors in the treatment or prevention of gastric stasis resulting from hypomotility of the stomach (with delayed emptying of the liquid and/or solid contents of the stomach).;More particularly said inhibitors are indazole derivatives such as (1H-indazol-6-yl)-cyclohexane or cyclohexene carboxylic acid derivatives, carbonitriles, amides or esters thereof. Gastric or gastrointestinal disorders, which may also be caused by adverse effects of therapeutic agents, of surgical operations or concomitant or secondary aspects of another disease, which include pain, nausea, vomiting, heartburn, postprandial discomfort, indigestion and gastro-esophageal reflux, can be prevented or treated with pharmaceutical compositions containing said PDE-4 indazole inhibitors.