METHOD OF PREPARING PREPARATION SHOWING FIBRINOLYTIC, ANTITHROMBOCYTIC, ANTICOAGULANT AND ANTIDIABETOGENIC ACTIVITIES

摘要

FIELD: medicine, physiology, pathophysiology, pharmacology. SUBSTANCE: the end product is isolated from peony roots bark (Paeonia lutea). Roots are peeled, washed with cold water and dried at 36.5-37.5 C for 23-25 h. Dried bark is separated, milled to granular-powder-like state, poured with 40% ethyl alcohol (10 ml of alcohol per 1 g of powder) and infused for 5-7 days in dark. Precipitate is removed and supernatant is brought about to the initial volume with distilled water. After oral administration of the preparation to animals the total fibrinolytic activity is increased by 1.6-fold, activity of plasminogen activator - by 2-fold, activated partial thromboplastin time is increased by 1.4-fold and blood glucose content in development of experimental insulin-dependent diabetes mellitus is decreased. Invention can be used for preparing biologically active preparation showing an anticoagulant effect. EFFECT: broadened assortment of preparations and their spectrum of effects. 3 cl, 1 tbl, 3 ex