HUMAN IMMUNOGLOBULIN SHOWING SPECIFICITY TO HUMAN PROTEIN L-SELECTIN

摘要

FIELD: biotechnology. SUBSTANCE: human immunoglobulin showing specificity to human protein L-selectin is chimeric immunoglobulin having regions that determine complementarity (CDR) corresponding to CDR-regions of murine donor immunoglobulin and carcass regions of variable site of heavy and light chain of human acceptor immunoglobulin and specifically binding with human L-selectin (affinity constant is 10⁷M^-1). Invention ensures to prepare nonimmunogeneous for human immunoglobulin showing specificity to protein L-selectin. EFFECT: improved method of preparing. 19 cl, 1 tbl, 6 dwg, 5 ex