Procedure for the manufacture of optically active aldehydes using transition metal phosphine complexes and procedure for the manufacture of an intermediate product in the manufacture of carbapenem antibiotics using these complexes

摘要

Novel phosphine compounds are represented by formulae (I) and (II): CHEM wherein the R substituents have the significations defined in the specification and are useful in the form of their transition metal complexes, or of compounds with transition metals, in producing an optically active aldehyde by hydroformylation of an olefin with high positional and steric selectivities. A 4-[(R)-1'-formylethyl]azetidin-2-one derivative obtainable by the process is particularly useful as an intermediate for the preparation of carbapenem antibiotics.