Preparation of 2-hydroxy-4-methylthiobutyric acid ester involves reacting 2-hydroxy-4-methylthiobutyronitrile with sulfuric acid and reacting 2-hydroxy-4-methylthiobutyramide with alcohol under same reaction medium

摘要

The preparation of 2-hydroxy-4-methylthiobutyric acid ester (HMTBE) involves: (1) reacting 2-hydroxy-4-methylthiobutyronitrile (HMTBN) with sulfuric acid to produce 2-hydroxy-4-methylthiobutyramide (HMTBM), and (2) reacting HMTBM with an alcohol to produce 2-hydroxy-4-methylthiobutyric acid ester. The two steps are carried out in same reaction medium.