Compounds of formula (I) or salts thereof: ##STR1## wherein R. sup. 1 is hydrogen, methoxy or formamido; R.sup.2 is an acyl group; CO. sub.2 R. sup.3 is a carboxy group or a carboxylate anion, or R.sup.3 is a carboxy protecting group, pharmaceutically acceptable salt-forming group or in vivo hydrolysable ester group; R.sup.4 represents hydrogen or up to four substituents; X is O, S, SO or SO.sub.2 ; Y is O, S, SO or SO. sub.2 ; n is 0 or 1; and m is 1 or 2. The compounds have antibacterial activity. Methods of synthesis of, and pharmaceutical formulations containing, compounds (I) are also described.
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机译:式(I)的化合物或其盐: 1是氢,甲氧基或甲酰胺基; R 2是一个酰基。 CO.sub.2 R.sup.3是羧基或羧酸根阴离子,或R.sup.3是羧基保护基,药学上可接受的成盐基团或体内可水解的酯基; R 4代表氢或最多四个取代基; X是O,S,SO或SO.sub.2; Y是O,S,SO或SO。 sub.2; n为0或1; m为1或2。这些化合物具有抗菌活性。还描述了化合物(I)的合成方法和包含其的药物制剂。
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