Method for Preparation of highly substituted compounds estereoquimicamente Controlled azaciclicos,Compounds obtained by this procedure yutilizacion of Oxides and sulfoximidas oxatiazol - for the preparation and use of Samarium iodide (ii) for the Desulphurization of Middle

摘要

Procedure for the stereochemically controlled preparation of novel and well-known highly substituted azacyclic compounds, particularly highly substituted pyrrolidines and piperidines, by reaction of optically active 2-alkenyl sulfoximide metal derivatives with alpha or beta-aminoaldehydes, with N protected, to give intermediates substituted azacylnes with sulfonimidoyl-methyl, which are desulfurized to give the desired cyclic compounds. The procedure gives rise to bulky azacyclic compounds. The process intermediates are novel azacyclnosulfonimidoyl-methyl,They were puzzled to give the required azercic compounds. This process produced new CIS compounds. The middle man of the process is the latest sulfur amide The iodine of samario (II) is used to desulfurize the known intermediate sulfur oxygen and oxatizol oxidant, so as to prepare azecilic compound by stereochemical control method,