Compounds derived from bencilideno - 1,3 Dihydro indole - 3 - one with anticancer activity, Pharmaceutical compositions, Process for their Preparation

摘要

Un compuesto derivado de bencilideno-1 3-dihidro-indol-2-ona de formula (I) en donde R1 es H u opcionalmente se une con R2 para formar un anillo fusionadoseleccionado del grupo que consiste en anillos arilo heteroarilo o heteroc clicos de 5 -Nr122so2r11, nr122c (nr12) nr11, cor11, co2r11, conr12211, so2nr1122r11, ocon122r11, and C (nr12) nr122r11, among which C1-12 can be selected from one or two groups of C (o).Or, s, s (o),SO2 or N12; alternatives called het, arilo or alipha C1-12 are 1 to 3r10; wherein R2 can optionally be combined with R3 to form a ring selected from 5-10 member arilo, heterocyclic or heterocyclic groups, which are composed of 0-3 heterocyclic atoms on the surface. Among them, 0-3 is n, 0-1 is heteromorphic atom, 0-1 is o or s, and one to three R9 can be selected to replace the combined ring; R4 is h, halogenated, NO2 or CN; R5 is the alimentary method of H, or C1-12, which is optionally replaced by one to three halogenated, hydroxy arylene; R6 and R7 are independent halogenated, CN, NO2, con10r11,-R11, n12r11, n12r11, n12r11, N1c (nr12) nr12r11; R10 is a substance independent of H, halogen, acrylic acid, acrylic acid, aril or het, in which C1-12 optionally inserts 1 to 2 groups of substances selected from O, s, s (or),SO2 o N12, where you say fat C1-12, arilo or het