Therapeutic combinations of estrogen receptor (serm) (selective) modulators and growth hormone secretagogues (ghs) to treat musculoskeletal fragility

摘要

Patent of Invention: B "THERAPEUTIC COMBINATIONS OF MODULATORS (SELECTIVE) OF ESTROGEN RECEPTOR (SERM) AND SECRETAGOGRAPHY OF GROWTH HORMONE (GHS) TO TREAT MUSCLE-SKELETAL FRAGILITY" D. This invention relates to combinations of pharmaceutical compositions and to methods containing (-) - cis-6-phenyl-5- (4- (2-pyrrolidin-1-yl-ethoxy) -phenyl) -5,6,7 , 8-tetrehydronaftale n-2-ol or a pharmaceutically acceptable salt thereof and 2-amino-N- (1 (R) - (2,4-difluoro-benzyloxymethyl) -2-oxo-2- (3-oso-3a (R) -pyridin-2-ylmethyl) -2- (2,2,2-trifluoro-ethyl) -2,3,3a, 4,6,7-hexahydro-pyrazole [4,3, -c] pyridin -5-yl) -ethyl) -2-methyl-propionamide or a pharmaceutically acceptable salt thereof, methods for using such compositions and kits containing such compositions. The compositions are useful for the treatment of musculoskeletal fragility, including osteoporosis, osteoporotic fracture, weak bone mass, fragility and weak muscle mass.