Indoles derived Compounds, Pharmaceutical composition useful for nervous system disorders, central nervous, gastrointestinal, obesity, Diabetes and sleep apnea.

摘要

A chemical compound of formula (i) in which R1 and R2 are independently selected from Hydrogen, halogen, alkyl, aryl, amino Hydroxy, alkoxy, alquilamino dialquilamino,,,Ariloxi, Alquiltio, alquilsulfoxilo, alquilsulfonilo, Nitro, carbonitrilo, carboalcoxi, and Selects carboariloxi carboxyl; R5 is Hydrogen, halogen, alkyl, aryl, Hydroxy, amino,Alquilamino, dialquilamino, alkoxy, ariloxi, Alquiltio, alquilsulfoxilo, alquilsulfonilo, Nitro, carbonitrilo, carboalcoxi,Carboariloxi and carboxyl; is a partially unsaturated Heterocyclic Ring or Aromatic Ring or a 5 or 6 links carbociclico partially unsaturated 5 or 6 layersIn that if a is a Ring carbociclico partially unsaturated 6 links, then at least one of R4 to R6 is different and the salts of hydrogen;Addition compounds and pharmaceutically acceptable prodrugs thereof; and the use of these Therapies, particularly as agonists or antagonists of 5-ht receptor.In particular, a 5-ht2c receptor, for example in the treatment of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders,Isipida and Gastrointestinal Disorders, diabetes, sleep apnea, and particularly for the treatment of Obesity.