A universally applicable blood plasma from a pooled source characterised by containing both residual red blood cells and the complete complement systems without any signs of complement activation during the use of the final product

摘要

A universally applicable blood plasma obtained by a process comprising the steps of mixing blood or blood plasma of blood groups A and B optionally blood or blood plasma of blood group AB without admixing substantial amounts of blood or blood plasma derived from blood group O. Preferably, the blood plasma has been prepared by pooled plasma derived from any donors. The pooled plasma is preferably virus inactivated prior to mixing blood or blood plasma of different blood groups A, B and AB. More than two thirds of all blood donors have free A and/or B substance in plasma. These substances are identical to A and B antigens bound to the surface of red blood cells. By mixing appropriate amounts of blood or blood plasma of the blood groups A, B and optionally AB anti-A and anti-B antibodies of subclasses IgM and IgG are neutralised by binding two free A and/or B substances and/or are removed during further processing.