Stable aqueous solution of em 12 (3 - (1 - oxo - 1,3 dihydro - isoindol - 2 - il) piperidin - 2.6 - dione) and preparation method of its solution

摘要

Refers to a stable aqueous solution of a Derivative of thalidomide in 12 ((1 - 3 - oxo - 1,3 dihydro - isoindol - 2 - il) piperidin - 2.6 - dione); at least 0,2 mg / ml; characterized by em 12 contain glucose dissolved in isotonic Solution, the solution pH = 5.5.It also refers to a process for the preparation of a stable aqueous solution of Derivative of thalidomide em 12 for parenteral Administration comprising: Dissolving Derivative of thalidomideIn 12,In an isotonic glucose solution of pH 4 to 5; Mixing and stirring until complete Dissolution for Shortening the preparation time; subjected to Ultrasound and filtered under Aseptic conditionsS. the solution in the form of Parenteral application and can be used for the therapy of inflammatory diseases and Hematology - Oncology