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APPLICATION OF QUINAZOLINE DERIVATIVES AS INHIBITORS OF THYROSINIC KINASE IN TREATING COLONIC POLYPS
APPLICATION OF QUINAZOLINE DERIVATIVES AS INHIBITORS OF THYROSINIC KINASE IN TREATING COLONIC POLYPS
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机译:喹唑啉衍生物作为甲状腺素激酶抑制剂在治疗结肠息肉中的应用
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摘要
This invention provides a method of treating or inhibiting colonic polyps in a mammal in need thereof which comprises administering to said mammal a compound having formula (I), wherein X is phenyl which is optionally substituted; R and R1 are each independently, hydrogen, halogen, alkyl, alkoxy, hydroxy or trifluoromethyl; R2 is hydrogen, alkyl, alkoxy, hydroxy or trifluoromethyl; Y is a radical selected from the group consisting of formulae (II), (III), (IV), (V), (VI), (VII) and (VIII). R3 is independently hydrogen, alkyl, carboxy, carboalkoxy, phenyl, or carboalkyl; n = 2-4; or a pharmaceutically acceptable salt thereof, with the proviso that each R3 of Y may be the same or different.
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机译:本发明提供了一种在有需要的哺乳动物中治疗或抑制结肠息肉的方法,该方法包括给予所述哺乳动物具有化学式(I)的化合物,其中X为可被取代的苯基;和R和R 1各自独立地是氢,卤素,烷基,烷氧基,羟基或三氟甲基; R 2是氢,烷基,烷氧基,羟基或三氟甲基; Y是选自由式(II),(III),(IV),(V),(VI),(VII)和(VIII)组成的组的基团。 R3独立地是氢,烷基,羧基,碳烷氧基,苯基或碳烷基; n = 2-4;或其药学上可接受的盐,条件是Y的每个R3可以相同或不同。
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