Hygromycin a derivatives (changed by the ISA to read hygromycin a derivatives as antibacterial agents.

摘要

This invention relates to compounds of formula (1)and to pharmaceutically acceptable salts and solvates thereof, wherein r1, r2, r3, x1 x2 are as defined herein. The compounds of formula (1)are antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula (1), methods of treating bacterial and protozoal infections by administering the compounds of formula (1), and methods of preparing certain compounds of formula (1).