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Products and methods for activating ppargamma-rxr and up-regulating monocyte/macrophage cd36 for the treatment of malaria
Products and methods for activating ppargamma-rxr and up-regulating monocyte/macrophage cd36 for the treatment of malaria
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机译:激活ppargamma-rxr和上调单核细胞/巨噬细胞cd36以治疗疟疾的产品和方法
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摘要
This invention relates to therapeutic products to treat iPlasmodium falciparum/i malaria. According to a first aspect of the invention, a composition for the treatment of malaria is disclosed. The composition includes, as an active ingredient, a PPAR gamma and/or a RXR agonist which upregulates monocyte/m phi CD36 in admixture with a pharmaceutically acceptable carrier, excipient or diluent. According to second aspect of the invention, a method of treating or preventing severe infection by iP. falciparum/i in a person is provided. The method includes the steps of: (a) forming a composition by combining a PPAR gamma and or a RXR agonist with an acceptable carrier, excipient or diluent; and (b) administering an effective dose of the composition to a person infected with or at risk of infection with iP. falciparum/i.
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机译:本发明涉及治疗恶性疟原虫疟疾的治疗产品。根据本发明的第一方面,公开了一种用于治疗疟疾的组合物。该组合物包括作为活性成分的PPARγ和/或RXR激动剂,其与药学上可接受的载体,赋形剂或稀释剂混合上调单核细胞/ m phi CD36。根据本发明的第二方面,一种治疗或预防由P引起的严重感染的方法。提供了人体内的恶性疟疾 i>。该方法包括以下步骤:(a)通过将PPARγ和/或RXR激动剂与可接受的载体,赋形剂或稀释剂混合形成组合物; (b)对感染或有感染iP风险的人给予有效剂量的组合物。恶心 i>。
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