PHARMACEUTICAL IMIDAZOLE COMBINATION FOR LOCALLY TREATING VULVOVAGINITIS AND VAGINOSIS

摘要

The invention concerns a pharmaceutical composition comprising a combination of at least two imidazole derivatives having reinforcing synergy against germs which cause infectious vulvovaginitis and vaginosis and selected from the group comprising metronidazole, econazole, miconazole, clotrimazole, terconazole, bifonazole, cloconazole, isoconazole, oxiconazole, sulconazole, tioconazole and their salts, preferably metronidazole combined with econazole. The composition is advantageously in galenic form of a hard or soft capsule having an solid hard or soft outer envelope containing gelatine, enclosing an internal non-aqueous lipophilic liquid or semi-liquid phase wherein the imidazole derivatives are suspended in a lipophilic agent, a water-dispersible agent and a bioadhesive agent.