1--1236-1-PHENYLALKYL-1236-TETRAHYDROPYRIDINES FOR TREATING ALZHEIMER'S DISEASE

摘要

The present invention relates to a compound of formula (I):; (Wherein, Y is -N- or -CH- and;; R ₁ Is hydrogen, halogen or _{CF 3, (C 1 -C 4} ) alkyl or (C ₁ -C ₄₎ alkoxy group;; R ₂ is a methyl or ethyl group;; R ₃ and R ₄ are each hydrogen or (C ₁ -C ₃₎ alkyl; And; X is _{(a) (C 1 -C 6} ) alkyl, (C ₁ -C ₆₎ alkoxy, (C ₃ -C ₇₎ carboxyalkyl, (C ₁ -C ₄₎ alkoxycarbonyl (C ₁ -C ₆₎ alkyl, (C ₃ -C ₇₎ alkoxy, or carboxy (C ₁ -C ₄₎ alkoxycarbonyl (C ₁ -C ₆₎ alkoxy;; _{(b) (C 3 -C 7} ) cycloalkyl, (C ₃ -C ₇₎ cycloalkoxy, (C ₃ -C ₇₎ cycloalkyl-methyl, (C ₃ -C ₇₎ cycloalkylamino and cyclohexenyl selected from hexenyl radical, which is halogen, hydroxyl, (C ₁ -C ₄₎ alkoxy, carboxyl, (C ₁ -C ₄₎ alkoxycarbonyl, amino or mono or di (C ₁ -C ₄₎ alkyl amino; or; (C) phenyl, phenoxy, phenylamino, N- (C ₁ -C ₃₎ alkyl-phenylamino, phenylmethyl, phenylethyl, phenyl-carbonyl, phenylthio, phenylsulfonyl, phenyl group selected from sulfinyl and styryl and, which said group is _{halogen, CF 3, (C 1 -C} 4) alkyl, cyano, amino, mono- or di - (C ₁ -C ₄₎ alkylamino, (C ₁ -C ₄₎ acyl o Mino, carboxyl, (C ₁ -C ₄₎ alkoxycarbonyl, aminocarbonyl, mono- or di - (C ₁ -C ₄₎ alkyl-aminocarbonyl, amino (C ₁ -C ₄₎ alkyl, hydroxy (C ₁ -C ₄₎ alkyl or halogeno (C ₁ -C ₄₎ may be mono-substituted or multi-substituted in the phenyl vapor by alkyl). The invention also relates to pharmaceutical compositions containing, and methods of producing him. The compounds have the nerves affected and neuroprotective activity.; [Formula I]