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Recombinant human histone protein, useful e.g. as anticancer or antibiotic agent, expressed in prokaryotic cells
Recombinant human histone protein, useful e.g. as anticancer or antibiotic agent, expressed in prokaryotic cells
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机译:重组人组蛋白,例如作为抗癌药或抗生素,在原核细胞中表达
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摘要
Recombinant human protein (I), having the biological activity of a histone 1 (H1), or its active fragments, produced in prokaryotic cells, especially Escherichia coli. An independent claim is also included for producing (I). - ACTIVITY : Anticancer; cytostatic; antibiotic; immunomodulatory; endocrinological; antibacterial; antiviral; antifungal; antiparasitic. When tested at 62 Microg/ml against K562 leukemia cells, recombinant histone H1.2 caused 63% cell death after 1 hour, but only 13% death of peripheral blood mononuclear cells. - MECHANISM OF ACTION : Histones are involved in organization of the chromatid structure and in gene repression. They create channels in cell membranes, increasing the permeability and leading to swelling and lysis.
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