new aspartyl - dipeptidderivate and saccharine

摘要

A low-calory sweetener is provided which is highly stable and safe and has a high sweetness potency. This sweetener comprises novel aspartyldipeptide derivatives of the following general formula (1) and their salts: L-Asp-X-NH-C*HR1R2 (1 wherein R1 represents an alkyl group having from 1 to 6 carbon atoms, or an alkoxymethyl group having from 2 to 7 carbon atoms; R2 represents a phenyl group, a benzyl group, a cyclohexyl group, or a cyclohexylmethyl group; the structure having the C* atom is of an (S) form when R1 is an alkyl group but is of an (R) form when R1 is an alkoxymethyl group; X represents a residue of a D- alpha -amino acid or DL- alpha -amino acid, or a residue of a cyclic or acyclic alpha , alpha -dialkylamino acid having from 3 to 6 carbon atoms, when R1 is an alkyl group, but X represents a residue of a D- alpha -amino acid or DL- alpha -amino acid, or a residue of a cyclic or acyclic alpha , alpha -dialkylamino acid having from 3 to 6 carbon atoms, when R1 is an alkoxymethyl group; and the bond between L-Asp and X is an alpha -bond.