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Palladium and boron co-catalyzed addition of oxygen nucleophiles to vinyl epoxides
Palladium and boron co-catalyzed addition of oxygen nucleophiles to vinyl epoxides
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机译:钯和硼共催化氧亲核体加成到乙烯基环氧化物中
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摘要
Nucleophilic oxygen species, such as primary alcohols, carboxylates, and water, are added to vinyl epoxides in a highly regioselective and enantioselective manner, providing a convenient route to enantiomerically enriched 1,2-diols and oxygen-containing heterocycles. The reaction employs a chiral Pd(0) complex and a borane or borate as co-catalysts Also described are similar additions of nitrogen nucleophiles, and the addition of carbonates to vinyl epoxides using a chiral Pd(0) catalyst.
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