Human fibroblast growth factor receptor 1 as a co-receptor for infection by adeno-associated virus 2

摘要

The present invention relates generally to the fields of gene therapy. More particularly, it concerns gene transfer using adeno-associated virus and methods of increasing transcription and promoting replication of transgenes. The present invention shows that AAV requires human fibroblast growth factor receptor 1 (FGFR1) as a co-receptor for successful viral entry into the host cell. Methods and compositions for exploiting this finding in AAV vector-mediated gene therapy are disclosed.