Immunogenic portion of human cytomegalovirus structural phosphoprotein, its production and use

摘要

The phosphorylated structural protein of molecular weight about 150 kd (pp 150) of human cytomegalovirus (HCMV) is highly immunogenic and is reliably recognised by human antisera. This protein can, after assignment to the genome of HCMV, be prepared in its entirety or in immunogenic fragments by genetic engineering. Proteins of this type are suitable as reagents, for example in an ELISA, and as components of vaccines.