A method for producing from human plasma pool fibrin glue forming component having a high safety against virus contamination

摘要

(57) yield, quality, and [Abstract] The present invention relates to a method for preparing the plasma pool biological tissue adhesive components having all of high safety against virus contamination. In a first aspect, the three-stage virus inactivation treatment product comprising fibrinogen, from factor XIII and fibronectin is obtained, where the solvent is a viral biocide in the beginning, concentrate the fibrinogen, factor XIII and fibronectin / was treated with a surfactant solution, followed nanofiltration then, heat treatment is performed at the end. In the method of the present invention, it does not compromise the recovery of high-quality products. In a second aspect, is performed in order to obtain a 3-step virus inactivated thrombin product, a process similar to the above process. In this case, it is improved to about twice the recovery of thrombin activity by improving the patents known processes.