METHOD FOR DETECTING MORBIDITY RISK OF SEQUENTIAL AA- AMYLOIDOSIS IN RHEUMATOID ARTHRITIS PATIENT AND NEW OLIGONUCLEOTIDE CONTAINING MONOBASIC PLEOMORPHISM IN SAA1 GENETIC LOCUS

摘要

PROBLEM TO BE SOLVED: To provide a method capable of detecting morbidity risk of sequential AA-amyloidosis of rheumatoid arthritis and to obtain a new oligonucleotide usable as a probe in the method.;SOLUTION: In this method for the detecting, the morbidity risk of sequential AA-amyloidosis of rheumatoid arthritis is detected by determining whether a base at the-13 of human serum amyloid is thymine or cytosine. The DNA contains a base sequence GCCACCGTTC CCTGG or a base sequence GCCACCGCTC CCTGG.;COPYRIGHT: (C)2002,JPO