Carbohydrate based lipid compositions and supramolecular structures comprising same

摘要

A lipid compound comprising: chemistry chemdraw filechemistry mol file;where C¹ to Cⁿ are stereochemical centers; n=5, 6, 7 or 8; R¹, R², R³, R⁴, R⁵ and R⁶ are the same or different, and are selected from the group consisting of H, OH, amine, thiol, methoxy, straight or branched chain ester of 6-50 carbon atoms, straight or branched chain silane of 6-50 carbon atoms, straight or branched chain amide of 6-50 carbon atoms, straight or branched chain urea of 6-50 carbon atoms, straight or branched chain urethane of 6-50 carbon atoms, straight or branched chain carbonate of 6-50 carbon atoms, straight or branched chain sulfate of 6-50 carbon atoms, straight or branched chain thiol-urethane of 6-50 carbon atoms, straight or branched chain phosphate of 6-50 carbon atoms, straight or branched chain amine of 6-50 carbon atoms, straight or branched chain thio-urea of 6-50 carbon atoms, straight or branched chain thio-ether of 6-50 carbon atoms, straight or branched chain thio-ester of 6-50 carbon atoms, straight or branched chain ether of 6-50 carbon atoms, and any combination thereof, wherein the chain is fully saturated, full unsaturated or any combination thereof; M and X1 are O, S, or N—R⁷, wherein R⁷ is H, a lower alkane, a chain as recited for R¹, R², R³, Se or any isoelectronic species of oxygen and a=0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; X² is phosphonate, phosphate, boronophosphate, thiophosphate, or selenophosphate and b is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; X³=methylene or a monomer selected from the group consisting of an ether, an ester, an amine, acrylic acid, amino acid, a nucleic acid, or a monosaccharide, and c=0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20; X⁴=hydroxide, N-succinyl derivative, a monomer selected from the group consisting of an amine, an ether, an ester, an amino acid, monosaccharide, and a nucleic acid, N—(R⁸)e where R⁸ is hydrogen or methylene chain of 1-20 carbons, or cyclic forms thereof d=0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 and e=1, 2 or 3.