Methods and systems for clinical analyte determination by visible and infrared spectroscopy

摘要

Noninvasive, in-vivo, methods and system for determining a person's relative individual percentages of a plurality of hemoglobin species and for determining a person's total hemoglobin concentration, as well as, the concentration of the hemoglobin species which contribute to this total concentration, i.e., oxy-, deoxy-, carboxy-, met- and suf- hemoglobin are described. In a first embodiment, analyte wavelengths are selected in the visible region from 510 nm to 620 nm, with separate analyte wavelengths for each hemoglobin species to determine relative individual percentages. The measurements are then combined in a series of simultaneous equations which are then solved for the concentration of each species and the total concentration of hemoglobin. In a second embodiment, wavelengths in the near infrared region from 650 nm to 1000 nm and derivative spectra are employed to determine total hemoglobin concentration, as well as, the concentration of the hemoglobin species which contribute to this total concentration.