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Agents that bind to and inhibit human cytochrome P450 1A2
Agents that bind to and inhibit human cytochrome P450 1A2
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机译:结合并抑制人类细胞色素P450 1A2的药物
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摘要
The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 1A2 having advantageous properties, including capacity substantially to inhibit enzyme activity of human cytochrome P450 1A2 and lack of specific binding to other human cytochromes P450. The binding agents of the invention are useful inter alia in methods for screening drugs for metabolism by cytochrome P450 1A2, and in methods of measuring p450 1A2 levels in individuals relative to p450 1A2 levels in a control population.
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