Increased immune response mediated by an antibody-cytokine fusion protein by coadministration with angiogenesis inhibitor

摘要

"INCREASED IMMUNE RESPONSE MEDIATED BY AN ANTIBODY-CYTOKIN FUSION PROTEIN BY CO-ADMINISTRATION WITH ANGIOGENESIS INHIBITOR". Compositions and methods for enhancing a cytocidal immune response directed against a cell of the pre-selected type in a mammal are disclosed. The methods and compositions rely on a combination of an anticorpocytokine immunoconjugate and an angiogenesis inhibitor. Once administered to the mammal, the immunoconjugate induces an immune response against the cell of the pre-selected type, for example, a cancer cell that, as a result of synergy with the angiogenesis inhibitor, is greater than the immune response induced by the immunoconjugate. in isolation. The methods and compositions are particularly useful in killing solid tumors or virally infected cells in a mammal.