Method for treating exercise induced Asthma induced by exercise

摘要

Medicine composition for Treatment of Asthma based on the inhibition of PDE catalytic form of R - 4 binds with low Affinity rolipram,The composition is characterized by a relationship of IC50 of 0,1 or more in connection with the IC50 for the form of PDE 4 binds with High affinity rolipram divided by the IC50 for the form that binds with low Affinity rolipram.Medicine composition for the treatment of exercise induced Asthma induced by cold air or Induced PollutionThey include the use of a specific inhibitor of PDE 4 in its catalytic R - rolipram binds with low Affinity, where the composition includes a compound whose IC50 ratio is 1.0 or more in connection with the IC50 for a form of PDE - R - 4 binds with High affinity rolipram, divided by the IC50 for the catalytic R - rolipram binds with low Affinity.Product according to claim 6 where the relationship of the IC50 of specific PDE 4 inhibitor used is 0.5 or more.