Condensed pyrrole carboxamides functioning as ligands of brain GABA-receptors

摘要

The invention discloses substituted methylpyrrol carboxamides,These compounds are GABAa brains receptor stimulating agent, antagonist or the reverse agonist of high selectivity,Or the prodrug of GABAa receptor stimulating agents, antagonist or reverse agonist,Therefore it can be used for diagnosing and treating anxiety, depression, senile dementia, sleep disturbance and epileptic attack, benzodiazepine overdose and improve memory capability. The present invention also provides pharmaceutical composition,Pharmaceutical composition including packaging. The compounds of this invention also acts as the probe that GABAa receptors position in tissue sample.