Dependent aminotransferase inhibitors of branched chain amino acid and its use in the treatment of Neurodegenerative Diseases (CHAID branched amino acid dependent aminotrans - ferase inHibitors and their use in the treatment of Neurodegenerative Diseases

摘要

The Invention relates to inhibitors of BCAT and its Utility in the Treatment or prevention of the neuronal loss associated with Myocardial Ischemia, trauma, CNS, and surgeries and hypoglycemia.Neurodegenerative Diseases including Alzheimer's disease, Amyotrophic lateral sclerosis, Huntington's disease and down's Syndrome.The Treatment or prevention of the adverse consequences of overstimulation of the excitatory amino acid, the treatment of anxiety, Psychosis, seizures,Hearing Loss induced by antibiotics with amino glycosides, Migraine headaches, Chronic Pain, neuropathic pain, Parkinson's disease, Diabetic Retinopathy, glaucoma,CMV retinitis, urinary incontinence, or opioid tolerance and withdrawal, Anesthesia Induction, as well as the Improvement of Cognition.