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METHOD OF PREVENTING NMDA RECEPTOR-MEDIATED NEURONAL DAMAGE.
METHOD OF PREVENTING NMDA RECEPTOR-MEDIATED NEURONAL DAMAGE.
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机译:预防NMDA受体介导的神经损伤的方法。
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摘要
Disclosed is a method for reducing non-ischemic NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a compound of the formula shown in FIG. 1 (or a physiologically-acceptable salt thereof), wherein R1 includes an amino group, R2-R17 are independently H or a short chain aliphatic group comprising 1-5 carbons, and R4 and R10 also may (independently) be a halogen or an acyl group. Also disclosed is a screen for antagonists of NMDA receptor mediated neurotoxicity which have an enhanced prospect for being clinically tolerated and selective against such neurotoxicity.
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