Polymorfe forbindelser av krystallinske (2-benzhydryl-1- azabicyklo(2.2.2)okt-3-yl)-(5-isopropyl-2-metoksybenzyl)-amin-citrat som NK-1-reseptorantagonister

摘要

Two crystalline polymorphic forms of (2-Benzhydryl-1-azo-bicyclo[2.2.2]oct-3-yl)-(5-isopropyl-2-methoxybenzyl)-amine citrate monohydrate (the monohydrates) are Form A and Form B. The pharmaceutical composition containing at least one of these polymorphs has advantageous stability for formulation to treat acute emesis in patient receiving chemotherapy. The administration of this pharmaceutical composition is conventional oral by preferably tablet or capsule and intravenous. A method of making A and B Forms is also disclosed.