This invention relates to the use of derivatives and analogs of formula (I) which possess adenosine agonist activity and are useful as anti-hypertensive and anti-ischemic agents, to pharmaceutical compositions including such compounds, and to their use in treating hypertension and myocardial ischemia, and to methods and intermediates used in the preparation of such compounds, CHEM wherein; K is CH; Q is CH2 or O: T is CHEM or R3O-CH2; X is straight or branched chain alkylene, cycloalkylene or cycloalkenylene group, each of which is optionally substituted by at least one CH3, CH3CH2, Cl, F, CF3 or CH3O; Y is NR4, O or S; a = 0 or 1; Z is of the formula CHEM Z1 is N, CR5, (CH)m-CR5 or (CH)m-N, m being 1 or 2; Z2 is N, NR6, O or S, n being 0 or 1; R1, R2, R3, R4, R5 and R6 are indepenfently H, alkyl, aryl or heterocyclyl; Ra, Rb, R', R'' as defined in the application.s
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