METHOD OF PRODUCING A MOUSE SUITABLE FOR ENGRAFTMENT, DIFFERENTIATION AND PROLIFERATION OF HETEROLOGOUS CELLS, MOUSE PRODUCED BY THIS METHOD AND USE OF THE MOUSE

摘要

An immunodeficient mouse (NOG mouse) suitable for the take, differentiationand proliferation of heterogeneous cells; and a method of constructing such amouse. This mouse is obtained by back crossing an NOD/Shi mouse with a C.B-17-scid mouse, and further crossing a thus obtained mouse with an interleukin 2-receptor .gamma.-chain gene-knockout mouse. It is usable in construction ahuman antibody, a stem cell assay system, and construction of a tumor modeland a virus-infection model.