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Mutations of the mdr1 p-glycoprotein that improve its ability to confer resistance to chemotherapeutic drugs
Mutations of the mdr1 p-glycoprotein that improve its ability to confer resistance to chemotherapeutic drugs
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机译:mdr1 p-糖蛋白的突变可提高其对化疗药物的耐药性
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摘要
The present invention provides mutant P-glycoprotein polypeptides that confer increased resistance to certain chemotherapeutic drugs relative to wild-type P-glycoprotein or P-glycoprotein having a glycine to valine substitution at position 185, and nucleic acid molecules encoding the same. The invention also provides antibodies that specifically bind mutant P-glycoproteins. The invention further provides methods for the diagnosis and treatment of conditions associated with P-glycoprotein-mediated multidrug resistance.
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