CELLULAR RECEPTOR MUTATIONS PREDICTED BY MULTIPLE-SEQUENCE-ALLIGNMENT

摘要

The invention relates to methods of predicting mutations that alter the activity of a receptor in a desired manner. The methods utilize multiple sequence alignment and phylogenetic profiling to identify the relatives of a given receptor that are most likely to provide useful data allowing prediction of sites to mutate in the given receptor. The methods provided are applicable to any type of receptor, and are particularly well suited for predicting sites to mutate in order to alter the activities of the so-called orphan receptors, for which no agonists are known.