The present invention relates to the isolation, cloning, and characterization of a prostate-specific PC-1 gene differentially expressed by prostate cells and tissues. The present invention additionally relates to replication-competent adenovirus vectors which are specific for cells which allow a PC-1 transcriptional regulatory sequence to function, such as prostate cancer cells, prostate stromal cells, breast cancer cells, renal cells, bladder cells, and cells of the endometrium, and methods of use of such viruses are provided. These viruses comprise an adenoviral gene under control of a PC-1 transcriptional regulatory sequence. Such replication-competent adenovirus vectors are useful in the treatment of prostate cancer, brain cancer, ovarian cancer, thyroid cancer, tumors, renal carcinoma, bladder cancer, lung cancer, or breast cancer.
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