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HEPATITIS B VIRUS (HBV) ANTIGENIC POLYPEPTIDE-HEAT SHOCK PROTEIN COMPLEX AND USE THEREOF
HEPATITIS B VIRUS (HBV) ANTIGENIC POLYPEPTIDE-HEAT SHOCK PROTEIN COMPLEX AND USE THEREOF
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机译:乙型肝炎病毒(HBV)抗原多肽-热休克蛋白复合物及其用途
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摘要
The present invention provides a kind of HBV-antigen bound to heat shock protein which comprises core antigen, surface antigen and polymerase antigen. The present invention also provides a complex of HBV antigen bound to heat shock protein gp96 and hsp78, as well as a method for preparing the complex. The complex includes a complex of gp96 and hsp78 non-covalently bound to antigenic polypeptide, as well as a fusion protein of the both which results from covalent binding. Such complex can be used to prepare therapeutic vaccine for treating hepatitis B and secondary hepatoma.
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