MAMMALIAN NON-ERYTHROID Rh TYPE C GENES AND GLYCOPROTEINS

摘要

The invention provides nucleic acid sequences encoding novel mammalian nonerythroid Rh type C glycoproteins, including the human homologue, RhCG and the mouse homologue, Rhcg. These Rhcg and RhCG glycoproteins have a characteristic twelve transmembrane domain structure and are predominantly expressed in kidney and testis. Also provided are recombinant vectors and host vector systems containing these nucleic acid sequences and fusion proteins incorporating fragments of Rhcg and RhCG glycoproteins. The invention further provides methods of detection of Rhcg and RhCG glycoproteins and also methods of detecting Rhcg and RhCG genes.