PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATMENT OF BRAIN INJURY, SPINAL CORD INJURY, STROKE, NEURODEGENERATIVE DISEASE AND OTHER CONDITIONS

摘要

Disclosed is a pharmaceutical composition comprising a substance that upon administration to a patient leads to an inhibition of extension of cellular processes of astrocytes and/or a retraction of said cellular processes. Disclosed is also use of said substance for the production of a pharmaceutical composition for treatment of a condition selected from the group consisting of brain injury, spinal cord injury, stroke, neurodegenerative diseases, neuronal and/or synaptic loss associated with ageing, disorders of the brain associated with ageing and diabetic retinopathy, and also a method for treatment of said conditions wherein said substance is administered to a patient. Examples of such substances are quercetin, endothelin, hyaluronectin, L2 antibody, L2 glycolipid, L2 tetrasaccharide, TGF-alpha, or a tyrosine phosphatase inhibitor such as orthovanadate or phenylarsine oxide.