COMPOSITIONS COMPRISING A COMBINATION OF BONE MORPHOGENETIC PROTEIN AND PARATHYROID HORMONE-RELATED PEPTIDE

摘要

Compositions of proteins with chondrocyte and cartilaginous tissue inducing activity, as well as method of using those compositions, are disclosed. The compositions comprise one or more proteins of the transforming growth factor- beta (TGF- beta ) superfamily of proteins, particularly bone morphogenetic proteins (BMPs), in combination with parathyroid hormone related polypeptide (PTHrP) or an equivalent PTH-like polypeptide. The compositions and methods are useful in the treatment of osteoarthritis, cartilage defects and in related tissue repair.