New intermediate for the preparation of amlodipine besylate and its process

摘要

PURPOSE: Provided are a novel intermediate for the preparation of amlodipine besylate and its process, which intermediate contains triazole group and used as a starting material in synthesizing amlodipine besylate environment friendly. CONSTITUTION: Triazone derivatives of the formula(5) is manufactured by the steps of: reacting ethanol amine and 1,3-dimethylhexahydro-2-oxo-1,3,5-triazine derivative to prepare a compound of the formula(6); introducing ketoester group thereinto to prepare a compound of the formula(7); reacting the compound of the formula(7) with 2-chlorobenzaldehyde in the presence of low alcoholic reaction solvent and followed by refluxing and neutralizing it; reacting resultant solution with methyl-3-aminochlotonate to obtain triazone compound of the formula(5).