2 3 Construction and application of a novel poliovirus vaccine vector with a cloning site between 2C and 3A coding region

摘要

The present invention is a CTL (Cytotoxic T lymphocyte) exhibit specificity for the cloning of foreign genes HBV (Hepatitis B virus) to the recombinant polio virus vectors with here capable of expressing a foreign gene between the non-protein of 2C and 3A coding region expressing the CTL epitopes reported to induce relates to pW3CDs, pW3CDc, and the resulting transformant was E.coli, and not to the part used for the expression of foreign genes in the poliovirus now expressing the foreign gene in the novel parts not only confirmed that it is possible to, associated with CTL induced by changing the CTL epitope sequence this way produced recombinant polio viruses such as viral hepatitis disease, AIDS, cancer inducing CTL, the CTL epitope expressed on this site from people which it can be used as a vaccine vector for the treatment of diseases that can be treated .