Tumor-Specific Recombinant Adenovirus and Method for Tumor-Specific Transformation by The Same

摘要

The present invention selectively removes only the gene encoding the 55kDa protein that binds the tumor suppressor gene p53 protein of the gene of the E1B region which is involved in self-proliferation of the adenovirus, and allows growth only in the tumor cell-specific, tumor through which by using a less restricted mutation type recombinant adenovirus and electrical virus to be able to kill the invention relates to a method for removing tumor cells. How to remove the tumor cells by using a recombinant adenovirus having a tumor specific killing ability of the invention to remove the 55kDa gene of the E1B region of the gene of the adenovirus recombinant adenovirus a small limit then allowed to proliferate them, purified the method comprising; Step infecting electric separate recombinant adenovirus in a tumor cell; And, a step of electrical recombinant adenovirus infected tumor cells cultured. Application of recombinant adenoviruses having such tumor specific killing function is not only to overcome the limitations of proliferative out conventional gene by introducing a gene therapeutic adenovirus showing a therapeutic effect locally in only the virus is introduced into cell therapy rather, it is to maximize the therapeutic effect via the existing combination therapies and cancer treatments such as radiation therapy, drug therapy, and introduction of viruses within the therapeutic gene, and used in the development of new cancer therapies that can overcome complement the disadvantages of each There will be.