Preparation of 4-methylacetophenone, used as intermediate in synthesis of agrochemicals and pharmaceuticals, by reacting p-tolyl-magnesium halide in ether and acetic anhydride at a set temperature

摘要

Preparation of isomer-pure 4-methylacetophenone (I) comprises reacting p-tolyl-magnesium halide (II) in suitable ethers with acetic anhydride (III) at -40 to +10 deg C, then working the reaction solution up in a suitable way and separating (I).