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Production of fluorinated benzaldehyde compounds, used as intermediates for production of pharmaceuticals, involves hydrogenation of corresponding benzoyl chloride using supported palladium catalyst and moderator
Production of fluorinated benzaldehyde compounds, used as intermediates for production of pharmaceuticals, involves hydrogenation of corresponding benzoyl chloride using supported palladium catalyst and moderator
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机译:用作药物生产中间体的氟化苯甲醛化合物的生产涉及使用负载的钯催化剂和缓和剂将相应的苯甲酰氯氢化
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摘要
A method for the production of fluorinated benzaldehydes (I) involves hydrogenation of the corresponding fluorinated benzoyl chloride with hydrogen in presence of a supported palladium catalyst and a catalyst moderator. A method for the production of fluorine-containing benzaldehydes of formula (I), in which [Image] n : 1 or 2; R1-R3H, fluorine, chlorine, bromine, or 1-6C alkyl, fluoroalkyl, fluoroalkoxy or fluoroalkylthio, with at least one of these groups being fluorine or a fluorinated group and not more than two of these groups being bromine, 1-6C fluoroalkoxy and/or 1-6C fluoroalkylthio , involves reacting the corresponding aromatic acid chloride (II) (with COCl instead of CHO in formula (I)) with hydrogen in presence of a supported palladium catalyst and a catalyst moderator.
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